What is MSM?
Methylsulfonylmethane (MSM) is a naturally occurring organosulfur compound widely used as a dietary supplement. It’s recognized for its antioxidant and anti-inflammatory properties, and it’s found in small amounts in certain foods and beverages like fruits, vegetables, grains, and milk. MSM is often marketed as a supplement to support joint health, reduce inflammation, and improve immune function.
Chemically, MSM contains sulfur, an essential mineral that plays a key role in maintaining the structure and function of the body’s proteins, enzymes, and tissues.
Why Do We Need MSM?
In today's world, chronic inflammation and oxidative stress have become central contributors to obesity-related diseases such as type 2 diabetes and cardiovascular disease (CVD). MSM has demonstrated potential in addressing these issues by:
- Acting as an anti-inflammatory agent by reducing pro-inflammatory cytokines like IL-6 and TNF-α.
- Functioning as an antioxidant, possibly protecting tissues from oxidative damage.
- Supporting lipid metabolism, particularly by increasing HDL (good cholesterol) levels.
These attributes make MSM an intriguing natural option for improving metabolic health, especially in individuals who are overweight or obese.
Key Compounds in MSM
MSM itself is a singular compound (C₂H₆O₂S), but its biological effects are linked to its sulfur content. This sulfur is essential for:
- The synthesis of amino acids like methionine and cysteine.
- Maintaining connective tissue and cartilage health.
- Detoxification processes in the liver.
Uses and Benefits of MSM
A recent randomized controlled trial published in Nutrients (2021) evaluated the effects of daily MSM supplementation on cardiometabolic health in overweight and obese adults. Here are the primary findings and benefits:
✅ Improved HDL Cholesterol
Participants who took 3 grams of MSM daily for 16 weeks showed a significant increase in high-density lipoprotein (HDL) cholesterol levels at weeks 8 and 16, suggesting better cardiovascular health. Every 1 mg/dL increase in HDL is linked to a 2–3% reduction in heart disease risk.
✅ Lower C-Reactive Protein (CRP)
CRP, a key marker of inflammation, remained stable in the MSM group but increased significantly in the placebo group—indicating a protective effect against inflammation for those taking MSM.
✅ No Major Side Effects
MSM supplementation was well-tolerated. No major adverse effects were reported, confirming its safety for long-term use at the studied dosage.
✅ Potential for Metabolic Health Support
Although no significant changes were observed in insulin sensitivity or fasting glucose in this study, prior research in animal models shows MSM may improve insulin sensitivity and help regulate glucose levels—especially under conditions of metabolic dysfunction.
Conclusion
MSM shows great promise as a supplement to support cardiometabolic health, particularly by increasing HDL cholesterol and potentially reducing inflammation in overweight and obese individuals. While more research is needed, especially in larger and more diverse populations, MSM is a safe and natural compound that could be a valuable addition to your wellness routine.
References
Miller, L., Thompson, K., Pavlenco, C., et al. (2021). The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients, 13(3620). https://doi.org/10.3390/nu13103620